Full details of Andy’s publications are available at his Google Scholar Page

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Hendrix A, Lippens L, Pinheiro C, Thery C, Martin-Jaular L, Lotvall J, Lasser C, Hill AF, Witwer WK. Extracellular Vesicle Analysis. Nature Reviews Methods Primers, 3, 56 (2023).

EL Johnston, L Zavan, NJ Bitto, S Petrovski, AF Hill, M Kaparakis-Liaskos. Planktonic and Biofilm-Derived Pseudomonas aeruginosa Outer Membrane Vesicles Facilitate Horizontal Gene Transfer of Plasmid DNA. Microbiology Spectrum, e05179-22

Cable J, Witwer KW, Coffey RJ, Milosavljevic A, von Lersner AK, Jimenez L, Pucci F, Barr MM, Dekker N, Barman B, Humphrys D, Williams J, de Palma M, Guo W, Bastos N, Hill AF, Levy E, Hantak MP, Crewe C, Aikawa E, Adamczyk AM, Zanotto TM, Ostrowski M, Arab T, Rabe DC, Sheikh A, da Silva DR, Jones JC, Okeoma C, Gaborski T, Zhang Q, Gololobova O. Exosomes, microvesicles, and other extracellular vesicles-a Keystone Symposia report. Ann N Y Acad Sci. 2023 Mar 18. doi: 10.1111/nyas.14974. 

Zavan L, Fang H, Johnston EL, Whitchurch C, Greening DW, Hill AF, Kaparakis-Liaskos M. The mechanism of Pseudomonas aeruginosa outer membrane vesicle biogenesis determines their protein composition. Proteomics, 2200464

Amarasinghe I, Phillips W, Hill AF, Cheng L, Helbig KJ, Willms E, Monson EA. Cellular communication through extracellular vesicles and lipid droplets. J Extracellular Biology. 2 (3), e77, 2023.

Zhao W, Spiers JG, Vassileff N, Khadka A, Jaehne EJ, van den Buuse M, Hill AF. microRNA-146a modulates behavioural activity, neuroinflammation, and oxidative stress in adult mice. Mol Cell Neurosci. 2023 Mar;124:103820. doi: 10.1016/j.mcn.2023.103820.

Korvenlaita N, Gómez-Budia M, Scoyni F, Pistono C, Giudice L, Eamen S, Loppi S, de Sande AH, Huremagic B, Bouvy-Liivrand M, Heinäniemi M, Kaikkonen MU, Cheng L, Hill AF, Kanninen KM, Jenster GW, van Royen ME, Ramiro L, Montaner J, Batkova T, Mikulik R, Giugno R, Jolkkonen J, Korhonen P, Malm T.J. Dynamic release of neuronal extracellular vesicles containing miR-21a-5p is induced by hypoxia. J Extracell Vesicles. 2023 Jan;12(1):e12297. doi: 10.1002/jev2.12297.


Huang Y, Driedonks TAP, Cheng L, Rajapaksha H, Turchinovich A, Routenberg DA, Nagaraj R, Redding-Ochoa J, Arab T, Powell BH, Pletnikova O, Troncoso JC, Zheng L, Hill AF, Mahairaki V, Witwer KW. Relationships of APOE Genotypes With Small RNA and Protein Cargo of Brain Tissue Extracellular Vesicles From Patients With Late-Stage AD. Neurol Genet. 2022 Oct 26;8(6):e200026.

Gilmore WJ, Johnston EL, Bitto NJ, Zavan L, O’Brien-Simpson N, Hill AF, Kaparakis-Liaskos M. Bacteroides fragilis outer membrane vesicles preferentially activate innate immune receptors compared to their parent bacteria. Front Immunol. 2022 Sep 20;13:970725. doi: 10.3389/fimmu.2022.970725.

Shippey LE, Campbell SG, Hill AF, Smith DP. Propagation of Parkinson’s disease by extracellular vesicle production and secretion. Biochem Soc Trans. 2022 Sep 16:BST20220204. doi: 10.1042/BST20220204.

Huang Y, Driedonks TAP, Cheng L, Rajapaksha H, Routenberg DA, Nagaraj R, Redding J, Arab T, Powell BH, Pletniková O, Troncoso JC, Zheng L, Hill AF, Mahairaki V, Witwer KW. Brain Tissue-Derived Extracellular Vesicles in Alzheimer’s Disease Display Altered Key Protein Levels Including Cell Type-Specific Markers. J Alzheimers Dis. 2022 Oct 1. doi: 10.3233/JAD-220322.

Khadka A, Spiers JG, Cheng L, Hill AF. Extracellular vesicles with diagnostic and therapeutic potential for prion diseases. Cell and Tissue Research, 2022.

Liu H, Wilson KR, Firth AM, Macri C, Schriek P, Blum AB, Villar J, Wormald S, Shambrook M, Xu B, Lim HJ, McWilliam HEG, Hill AF, Edgington-Mitchell LE, Caminschi I, Lahoud MH, Segura E, Herold MJ, Villadangos JA, Mintern JD. Ubiquitin-like protein 3 (UBL3) is required for MARCH ubiquitination of major histocompatibility complex class II and CD86Nature Communications;13, 1934 (2022).

Watson OT, Buchmann G, Young P, Lo K, Remnant EJ, Yagound B, Shambrook M, Hill AF, Oldroyd BP, Ashe A. Abundant small RNAs in the reproductive tissues and eggs of the honey bee, Apis melliferaBMC Genomics, 2022; 23:257.

Hill AF, Sahoo S. Launching the Journal of Extracellular Biology (J Ex Bio) – A new journal from the International Society for Extracellular Vesicles (ISEV)Journal of Extracellular Biology, 2022; 1:e19.

Espejo C, Wilson R, Pye RJ, Ratcliffe JC, Ruiz-Aravena M, Willms E, Wolfe BW, Hamede R, Hill AF, Jones ME, Woods GM, Lyons AB. Cathelicidin-3 Associated With Serum Extracellular Vesicles Enables Early Diagnosis of a Transmissible Cancer. Front. Immunol., 29 March 2022 |

Cheng L, Hill AF. Therapeutically harnessing extracellular vesicles. Nature Reviews Drug Discovery, 2022; 1-21.

Spiers JG, Vassileff N, Hill AF. Neuroinflammatory Modulation of Extracellular Vesicle Biogenesis and Cargo LoadingNeuromolecular Medicine. 2022,

Spiers JG, Tan LS, Anderson ST, Hill AF, Lavidis NA, Chen H-JC. Hepatic Homeostasis of Metal Ions Following Acute Repeated Stress Exposure in Rats. Antioxidants. 2022, 11(1), 85;


Witwer KW, Goberdhan DC, O’Driscoll L, Théry C, Welsh JA, Blenkiron C, Buzás EI, Di Vizio D, Erdbrügger U, Falcón-Pérez JM, Fu QL, Hill AF, Lenassi M, Lötvall J, Nieuwland R, Ochiya T, Rome S, Sahoo S, Zheng L. Updating MISEV: Evolving the minimal requirements for studies of extracellular vesicles. J Extracell Vesicles. 2021 Dec;10(14):e12182. doi: 10.1002/jev2.12182.

Bitto NJ, Zavan L, Johnston EL, Stinear TP, Hill AF, Kaparakis-Liaskos M. Considerations for the Analysis of Bacterial Membrane Vesicles: Methods of Vesicle Production and Quantification Can Influence Biological and Experimental Outcomes. Microbiology Spectrum; Volume 9  Issue 3  e01273-21.

Couch Y, Buzas EI, Di Vizio D, Gho YS, Harrison P, Hill AF, Lotvall J, Raposo G, Stahl PD, Thery C, Witwer KW, Carter DRF. A brief history of nearly EV-erything – The rise and rise of extracellular vesicles. J Extracellular Vesicles 2021

Espejo C, Wilson R, Willms E, Ruiz-Aravena M, Pye RJ, Jones ME, Hill AF, Woods GM, Lyons AB. Extracellular vesicle proteomes of two transmissible cancers of Tasmanian devils reveal tenascin-C as a serum-based differential diagnostic biomarker. Cell Mol Life Sci 2021 Oct 16. doi: 10.1007/s00018-021-03955-y.

Samuel M, Fonseka P, Sanwlani R, Gangoda L, Chee SH, Keerthikumar S, Spurling A, Chitti SV, Zanker D, Ang C-S, Atukorala I, Kang T, Shahi S, Marzan AL, Nedeva C, Vennin C, Lucas MC, Cheng L, Herrmann D, Pathan M, Chisanga D, Warren SC, Zhao K, Abraham N, Anand S, Boukouris S, Adda CG, Jiang L, Shekhar TM, Baschuk N, Hawkins CJ, Johnston AJ, Orian JM, Hoogenraad NJ, Poon IK, Hill AF, Jois M, Timpson P, Parker BS, Mathivanan S. Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumour but accelerates cancer metastasis. Nature Communications; 123950 (2021).

Uta Erdbrügger, Charles J. Blijdorp, Irene V. Bijnsdorp, Francesc E. Borràs, Dylan Burger, Benedetta Bussolati, James Brian Byrd, Aled Clayton, James W. Dear, Juan M. Falcón-Pérez, Cristina Grange, Andrew F. Hill, Harry Holthöfer, Ewout J. Hoorn, Guido Jenster, Connie R. Jimenez, Kerstin Junker, John Klein, Mark A. Knepper, Erik H. Koritzinsky, James M. Luther, Metka Lenassi, Janne Leivo, Inge Mertens, Luca Musante, Eline Oeyen, Maija Puhka, Martin E. van Royen, Catherine Sánchez, Carolina Soekmadji, Visith Thongboonkerd, Volkert van Steijn, Gerald Verhaegh, Jason P. Webber, Kenneth Witwer, Peter S.T. Yuen, Lei Zheng, Alicia Llorente, Elena S. Martens-Uzunova. Urinary extracellular vesicles: A position paper by the Urine Task Force of the International Society for Extracellular Vesicles. J Extracell Vesicles. 2021;10:e12093.

Su H, Rustam YH, Masters CL, Makalic E, McLean CA, Hill AF, Barnham KJ, Reid GE, Vella LJ. Characterisation of brain-derived extracellular vesicle lipids in Alzheimer’s disease. J Extracell Vesicles. 2021;10:e12089

Foers AD, Garnham AL, Chatfield S, Smyth GK, Cheng L, Hill AF, Wicks IP, Pang KC. Extracellular Vesicles in Synovial Fluid from Rheumatoid Arthritis Patients Contain miRNAs with Capacity to Modulate Inflammation. Int. J. Mol. Sci. 2021, 22, 4910.

Phillips W, Willms E, Hill AF. Understanding extracellular vesicle and nanoparticle heterogeneity: Novel methods and considerations. Proteomics. 2021; e2000118/ doi:10.1002/pmic.202000118.

Gimona M, Brizzi MF, Choo ABH, Dominici M, Davidson SM, Grillari J, Hermann DM, Hill AF, de Kleijn D, Lai RC, Lai CP, Lim R, Monguio-Tortajada M, Muraca M, Ochiya T, Ortiz LA, Toh WE, Yi YW, Witwer KW, Giebel B, Lim SK. Critical Considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesiclesCytotherapy. 2021. May;23(5):373-380.

Bitto NJ, Cheng L, Johnston EL, Pathirana R, Phan TK, Poon IKH, O’Brien-Simpson NM, Hill AF, Stinear TP, Kaparakis-Liaskos M. Staphylococcus aureus membrane vesicles contain immunostimulatory DNA, RNA and peptidoglycan that activate innate immune receptors and induce autophagy. J Extracell Vesicles. 2021. 10(6), e12080.

Cheng L, Quek C, Li X, Bellingham SA, Ellett LJ, Shambrook M, Zafar S, Zerr I, Lawson VA, Hill AF. Distribution of microRNA profiles in pre-clinical and clinical forms of murine and human prion disease. Commun Biol. 2021 Mar 25;4(1):411.

Spiers JG, Steiger N, Khadka A, Juliani J, Hill AF, Lavidis NA, Anderson ST, Chen H-J C. Repeated acute stress modulates hepatic inflammation and markers of macrophage polarisation in the ratBiochimie, 2021;180:30-42.


Ugalde CL, Gordon SE, Shambrook M, Kenari AN, Coleman BM, Perugini MA, Lawson VA, Finkelstein DI, Hill AF. An intact membrane is essential for small extracellular vesicle-induced modulation of α-synuclein fibrillizationJ Extracell Vesicles2020 Dec;10(2):e12034. doi: 10.1002/jev2.12034.

Vassileff N, Cheng L, Hill AF. Extracellular vesicles – propagators of neuropathology and sources of potential biomarkers and therapeutics for neurodegenerative diseases. J Cell Science2020 Dec 11;133(23):jcs243139. doi: 10.1242/jcs.243139.

Foers AD, Dagley LF, Chatfield S, Webb AI, Cheng L, Hill AF, Wicks IP, Pang KC. Proteomic analysis of extracellular vesicles reveals an immunogenic cargo in rheumatoid arthritis synovial fluid. Clinical & Translational Immunology, 2020.

Chen H-J C, Yip T, Lee JK, Juliani J, Sernia C, Hill AF, Lavidis NA, Spiers JG.  Restraint Stress Alters Expression of Glucocorticoid Bioavailability Mediators, Suppresses Nrf2, and Promotes Oxidative Stress in Liver Tissue. Antioxidants, 20209(9), 853;

Ditiatkovski M, Mukhamedova N, Dragoljevic D, Hoang A, Low H, Pushkarsky, Fu Y, Carmichael I, Hill AF, Murphy AJ, Bukrinsky M, Sviridov D. Modification of lipid rafts by extracellular vesicles carrying HIV-1 protein Nef induces redistribution of APP and Tau causing neuronal dysfunction. Journal of Biological Chemistry 2020. doi: 10.1074/jbc.RA120.014642

Vassileff N, Vella LJ, Rajapaksha H, Shambrook M, Kenari AN, McLean C, Hill AF, Cheng L. Revealing the Proteome of Motor Cortex Derived Extracellular Vesicles Isolated from Amyotrophic Lateral Sclerosis Human Postmortem TissuesCells 2020, 9(7), 1709;

Huang Y, Cheng L, Turchinovich A, Mahairaki V, Troncoso JC, Pletnikova O, Haughey NJ, Vella LJ, Hill AF, Zheng L, Witwer KW. Influence of species and processing parameters on recovery and content of brain tissue-derived extracellular vesicles. Journal of Extracellular Vesicles, 9:1, 1785746.

Cheng L, Vella LJ, Barnham KJ, McLean C, Masters CL, Hill AF. Small RNA fingerprinting of Alzheimer’s disease frontal cortex extracellular vesicles and their comparison with peripheral extracellular vesicles. Journal of Extracellular Vesicles, 9:1, 1766822.

Foers AD, Garnham AL, Smyth GK, Proudman SM, Cheng L, Hill AF, Pang KC, Wicks IP. Circulating Small Non-Coding RNA Biomarkers of Response to Triple DMARD Therapy in Caucasian Women With Early Rheumatoid Arthritis. J Rheumatol. 2020 Jun 15:jrheum.191012. doi: 10.3899/jrheum.191012. Online ahead of print.

Börger V, Weiss DJ, Anderson JD, Borràs FE, Bussolati B, Carter DRF, Dominici M, Falcón-Pérez JM, Gimona M, Hill AF, Hoffman AM, de Kleijn D, Levine BL, Lim R, Lötvall J, Mitsialis SA, Monguió-Tortajada M, Muraca M, Nieuwland R, Nowocin A, O’Driscoll L, Ortiz LA, Phinney DG, Reischl I, Rohde E, Sanzenbacher R, Théry C, Toh WS, Witwer KW, Lim SK, Giebel B.  ISEV and ISCT Statement on EVs From MSCs and Other Cells: Considerations for Potential Therapeutic Agents to Suppress COVID-19Cytotherapy2020 May 16. doi: 10.1016/j.jcyt.2020.05.002.

Ugalde CL, Lewis V, Stehmann C, McLean CA, Lawson VA, Collins SJ, Hill AF. Markers of A1 astrocytes stratify to molecular subtypes in sporadic Creutzfeldt-Jakob disease brain. Brain Communications. fcaa029,

Kenari AN, Cheng L, Hill AF. Methods for loading therapeutics into extracellular vesicles and generating extracellular vesicles mimetic-nanovesicles. Methods. 2020 Jan 6. pii: S1046-2023(19)30266-X. doi: 10.1016/j.ymeth.2020.01.001

I Mäger, E Willms, S Bonner, AF Hill, MJA Wood. Extracellular vesicles in neurodegenerative disordersExosomes – a clinical compendium (eds Edelstein, Smythies, Noble). pp285-305.

Ugalde CL, Annesley SJ, Gordon S, Mroczek K, Perugini MA, Lawson VA, Fisher PR, Finkelstein DI, Hill AF. Misfolded α-synuclein causes hyperactive respiration without functional deficit in live neuroblastoma cells. Dis Model Mech. 2020 Jan 17;13(1):dmm040899. doi: 10.1242/dmm.040899.


Greening DW, Notaras M, Chen M, Xu R, Smith JD, Cheng L, Simpson RJ, Hill AF, van den Buuse M. Chronic methamphetamine interacts with BDNF Val66Met to remodel psychosis pathways in the mesocorticolimbic proteome. Mol Psychiatry. 2019 Dec 10. doi: 10.1038/s41380-019-0617-8. [Epub ahead of print]

Hill AF. Extracellular Vesicles and Neurodegenerative Diseases. J Neurosci. 2019 Nov 20;39(47):9269-9273. doi: 10.1523/JNEUROSCI.0147-18.2019.

Zhao W, Cheng L, Quek C, Bellingham SA, Hill AF. Novel miR-29b target regulation patterns are revealed in two different cell lines. Sci Rep. 2019 Nov 25;9(1):17449. doi: 10.1038/s41598-019-53868-x.

Tiihonen J, Koskuvi M, Storvik M, Hyötyläinen I, Gao Y, Puttonen KA, Giniatullina R, Poguzhelskaya E, Ojansuu I, Vaurio O, Cannon TD, Lönnqvist J, Therman S, Suvisaari J, Kaprio J, Cheng L, Hill AF, Lähteenvuo M, Tohka J, Giniatullin R, Lehtonen Š, Koistinaho J. Sex-specific transcriptional and proteomic signatures in schizophrenia. Nat Commun. 2019 Sep 2;10(1):3933. doi: 10.1038/s41467-019-11797-3.

Yap T, Seers C, Koo K, Cheng L, Vella LJ, Hill AF, Reynolds E, Nastri A, Cirillo N, McCullough M. Non-invasive screening of a microRNA-based dysregulation signature in oral cancer and oral potentially malignant disorders. Oral Oncol. 2019 Sep;96:113-120. doi: 10.1016/j.oraloncology.2019.07.013.

Ugalde CL, Lawson VA, Finkelstein DI, Hill AF. The role of lipids in α-synuclein misfolding and neurotoxicity. J Biol Chem. 2019 May 7. pii: jbc.REV119.007500. doi: 10.1074/jbc.REV119.007500.

Witwer KW, Van Balkom BWM, Bruno S, Choo A, Dominici M, Gimona M, Hill AF, De Kleijn D, Koh M, Lai RC, Mitsialis SA, Ortiz LA, Rohde E, Asada T, Toh WS, Weiss DJ, Zheng L, Giebel B, Lim SK. Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications. J Extracell Vesicles. 2019 Apr 29;8(1):1609206. doi: 10.1080/20013078.2019.1609206.

Low H, Hoang A, Pushkarsky T, Dubrovsky L, Dewar E, Di Yacovo MS, Mukhamedova N, Cheng L, Downs C, Simon G, Saumoy M, Hill AF, Fitzgerald ML, Nestel P, Dart A, Hoy J, Bukrinsky M, Sviridov D.HIV disease, metabolic dysfunction and atherosclerosis: A three year prospective study. PLoS One. 2019 Apr 18;14(4):e0215620. doi: 10.1371/journal.pone.0215620.

Kenari AN, Kastaniegaard K, Greening DW, Shambrook M, Stensballe A, Cheng L, Hill AF. Exosome-mimetic nanovesicles contain distinct proteome and post-translational modified protein cargo, in comparison to exosomes. Proteomics. 2019 Feb 20:e1800161. doi: 10.1002/pmic.201800161. [Epub ahead of print]

Luu L, Ciccotosto GD, Vella LJ, Cheng L, Roisman LC, Multhaup G, Hill AF, Munter LM, Cappai R. Amyloid Precursor Protein Dimerisation Reduces Neurite Outgrowth. Mol Neurobiol. 56:13-28. 2019

Cimdins K, Waugh HS, Chrysostomou V, Lopez Sanchez MIG, Johannsen VA, Cook MJ, Crowston JG, Hill AF, Duce JA, Bush AI, Trounce IA. Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity. Mol Neurobiol. 2019 Jan 5. doi: 10.1007/s12035-018-1460-7. [Epub ahead of print]


Théry C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, Antoniou A, Arab T, Archer F, Atkin-Smith GK, Ayre DC, Bach JM, Bachurski D, Baharvand H, Balaj L, Baldacchino S, Bauer NN, Baxter AA, Bebawy M, Beckham C, Bedina Zavec A, Benmoussa A, Berardi AC, Bergese P, Bielska E, Blenkiron C, Bobis-Wozowicz S, Boilard E, Boireau W, Bongiovanni A, Borràs FE, Bosch S, Boulanger CM, Breakefield X, Breglio AM, Brennan MÁ, Brigstock DR, Brisson A, Broekman ML, Bromberg JF, Bryl-Górecka P, Buch S, Buck AH, Burger D, Busatto S, Buschmann D, Bussolati B, Buzás EI, Byrd JB, Camussi G, Carter DR, Caruso S, Chamley LW, Chang YT, Chen C, Chen S, Cheng L, Chin AR, Clayton A, Clerici SP, Cocks A, Cocucci E, Coffey RJ, Cordeiro-da-Silva A, Couch Y, Coumans FA, Coyle B, Crescitelli R, Criado MF, D’Souza-Schorey C, Das S, Datta Chaudhuri A, de Candia P, De Santana EF, De Wever O, Del Portillo HA, Demaret T, Deville S, Devitt A, Dhondt B, Di Vizio D, Dieterich LC, Dolo V, Dominguez Rubio AP, Dominici M, Dourado MR, Driedonks TA, Duarte FV, Duncan HM, Eichenberger RM, Ekström K, El Andaloussi S, Elie-Caille C, Erdbrügger U, Falcón-Pérez JM, Fatima F, Fish JE, Flores-Bellver M, Försönits A, Frelet-Barrand A, Fricke F, Fuhrmann G, Gabrielsson S, Gámez-Valero A, Gardiner C, Gärtner K, Gaudin R, Gho YS, Giebel B, Gilbert C, Gimona M, Giusti I, Goberdhan DC, Görgens A, Gorski SM, Greening DW, Gross JC, Gualerzi A, Gupta GN, Gustafson D, Handberg A, Haraszti RA, Harrison P, Hegyesi H, Hendrix A, Hill AF, Hochberg FH, Hoffmann KF, Holder B, Holthofer H, Hosseinkhani B, Hu G, Huang Y, Huber V, Hunt S, Ibrahim AG, Ikezu T, Inal JM, Isin M, Ivanova A, Jackson HK, Jacobsen S, Jay SM, Jayachandran M, Jenster G, Jiang L, Johnson SM, Jones JC, Jong A, Jovanovic-Talisman T, Jung S, Kalluri R, Kano SI, Kaur S, Kawamura Y, Keller ET, Khamari D, Khomyakova E, Khvorova A, Kierulf P, Kim KP, Kislinger T, Klingeborn M, Klinke DJ 2nd, Kornek M, Kosanović MM, Kovács ÁF, Krämer-Albers EM, Krasemann S, Krause M, Kurochkin IV, Kusuma GD, Kuypers S, Laitinen S, Langevin SM, Languino LR, Lannigan J, Lässer C, Laurent LC, Lavieu G, Lázaro-Ibáñez E, Le Lay S, Lee MS, Lee YXF, Lemos DS, Lenassi M, Leszczynska A, Li IT, Liao K, Libregts SF, Ligeti E, Lim R, Lim SK, Linē A, Linnemannstöns K, Llorente A, Lombard CA, Lorenowicz MJ, Lörincz ÁM, Lötvall J, Lovett J, Lowry MC, Loyer X, Lu Q, Lukomska B, Lunavat TR, Maas SL, Malhi H, Marcilla A, Mariani J, Mariscal J, Martens-Uzunova ES, Martin-Jaular L, Martinez MC, Martins VR, Mathieu M, Mathivanan S, Maugeri M, McGinnis LK, McVey MJ, Meckes DG Jr, Meehan KL, Mertens I, Minciacchi VR, Möller A, Møller Jørgensen M, Morales-Kastresana A, Morhayim J, Mullier F, Muraca M, Musante L, Mussack V, Muth DC, Myburgh KH, Najrana T, Nawaz M, Nazarenko I, Nejsum P, Neri C, Neri T, Nieuwland R, Nimrichter L, Nolan JP, Nolte-‘t Hoen EN, Noren Hooten N, O’Driscoll L, O’Grady T, O’Loghlen A, Ochiya T, Olivier M, Ortiz A, Ortiz LA, Osteikoetxea X, Østergaard O, Ostrowski M, Park J, Pegtel DM, Peinado H, Perut F, Pfaffl MW, Phinney DG, Pieters BC, Pink RC, Pisetsky DS, Pogge von Strandmann E, Polakovicova I, Poon IK, Powell BH, Prada I, Pulliam L, Quesenberry P, Radeghieri A, Raffai RL, Raimondo S, Rak J, Ramirez MI, Raposo G, Rayyan MS, Regev-Rudzki N, Ricklefs FL, Robbins PD, Roberts DD, Rodrigues SC, Rohde E, Rome S, Rouschop KM, Rughetti A, Russell AE, Saá P, Sahoo S, Salas-Huenuleo E, Sánchez C, Saugstad JA, Saul MJ, Schiffelers RM, Schneider R, Schøyen TH, Scott A, Shahaj E, Sharma S, Shatnyeva O, Shekari F, Shelke GV, Shetty AK, Shiba K, Siljander PR, Silva AM, Skowronek A, Snyder OL 2nd, Soares RP, Sódar BW, Soekmadji C, Sotillo J, Stahl PD, Stoorvogel W, Stott SL, Strasser EF, Swift S, Tahara H, Tewari M, Timms K, Tiwari S, Tixeira R, Tkach M, Toh WS, Tomasini R, Torrecilhas AC, Tosar JP, Toxavidis V, Urbanelli L, Vader P, van Balkom BW, van der Grein SG, Van Deun J, van Herwijnen MJ, Van Keuren-Jensen K, van Niel G, van Royen ME, van Wijnen AJ, Vasconcelos MH, Vechetti IJ Jr, Veit TD, Vella LJ, Velot É, Verweij FJ, Vestad B, Viñas JL, Visnovitz T, Vukman KV, Wahlgren J, Watson DC, Wauben MH, Weaver A, Webber JP, Weber V, Wehman AM, Weiss DJ, Welsh JA, Wendt S, Wheelock AM, Wiener Z, Witte L, Wolfram J, Xagorari A, Xander P, Xu J, Yan X, Yáñez-Mó M, Yin H, Yuana Y, Zappulli V, Zarubova J, Žėkas V, Zhang JY, Zhao Z, Zheng L, Zheutlin AR, Zickler AM, Zimmermann P, Zivkovic AM, Zocco D, Zuba-Surma EK. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. 2018 Nov 23;7(1):1535750. doi: 10.1080/20013078.2018.1535750.

Soekmadji C, Hill AF, Wauben MH, Buzás EI, Di Vizio D, Gardiner C, Lötvall J, Sahoo S, Witwer KW. Towards mechanisms and standardization in extracellular vesicle and extracellular RNA studies: results of a worldwide survey. J Extracell Vesicles. 2018 Oct 24;7(1):1535745. doi: 10.1080/20013078.2018.1535745.

Beauchamp LC, Chan J, Hung LW, Padman BS, Vella LJ, Liu XM, Coleman B, Bush AI, Lazarou M, Hill AF, Jacobson L, Barnham KJ. Ablation of tau causes an olfactory deficit in a murine model of Parkinson’s disease. Acta Neuropathol Commun. 2018 Jul 5;6(1):57-69. doi: 10.1186/s40478-018-0560-y.

McKenzie-Nickson S, Chan J, Perez K, Hung LW, Cheng L, Sedjahtera A, Gunawan L, Adlard PA, Hayne DJ, McInnes LE, Donnelly PS, Finkelstein DI, Hill AF, Barnham KJ. Modulating Protein Phosphatase 2A Rescues Disease Phenotype in Neurodegenerative Tauopathies. ACS Chem Neurosci. 2018 Jul 3. doi:10.1021/acschemneuro.8b00161.

Turner L, Bitto NJ, Steer DL, Lo C, D’Costa K, Ramm G, Shambrook M, Hill AF, Ferrero RL, Kaparakis-Liaskos M. Helicobacter pylori Outer Membrane Vesicle Size Determines Their Mechanisms of Host Cell Entry and Protein Content. Front Immunol. 2018 Jul 2;9:1466. doi: 10.3389/fimmu.2018.01466. eCollection 2018.

Foers AD, Chatfield S, Dagley LF, Scicluna BJ, Webb AI, Cheng L, Hill AF, Wicks IP, Pang KC. Enrichment of extracellular vesicles from human synovial fluid using size exclusion chromatography. J Extracell Vesicles. 2018 Jun 26;7(1):1490145. doi: 10.1080/20013078.2018.1490145.

Yap T, Koo K, Cheng L, Vella LJ, Hill AF, Reynolds EC, Nastri AL, Cirillo N, Seers CA, McCullough M. Predicting the presence of oral squamous cell carcinoma using commonly dysregulated microRNA in oral swirls. Cancer Prev Res (Phila). 2018 May 15. pii: canprevres.0409.2017. doi: 10.1158/1940-6207.CAPR-17-0409.

Clayton A, Buschmann D, Byrd JB, Carter DRF, Cheng L, Compton C, Daaboul G, Devitt A, Falcon-Perez JM, Gardiner C, Gustafson D, Harrison P, Helmbrecht C, Hendrix A, Hill AF, Hoffman A, Jones JC, Kalluri R, Kang JY, Kirchner B, Lasser C, Lawson C, Lenassi M, Levin C, Llorente A, Martens-Uzunova ES, Moller A, Musante L, Welsh JA, Witwer KW, Yin H, Nieuwland R. Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham UK, during December 2017J Extracell Vesicles. 2018, vol 7, 1473707.

Cheng L, Zhao W, Hill AF. Exosomes and their role in the intercellular trafficking of normal and disease associated prion proteins. Mol Aspects Med. 2018 Apr;60:62-68. doi: 10.1016/j.mam.2017.11.011.

Paquet-Fifield S, Koh SL, Cheng L, Beyit LM, Shembrey CE, Moelck C, Behrenbruch C, Papin M, Gironella M, Guelfi S, Nasr R, Grillet F, Prudhomme M, Bourgaux JF, Castells A, Pascussi JM, Heriot AG, Puisieux A, Davis MJ, Pannequin J, Hill AF, Sloan EK, Hollande F. Tight junction protein claudin-2 promotes self-renewal of human colorectal cancer stem-like cells. Cancer Res. 2018 Mar 6;78(11):2925-2938. doi: 10.1158/0008-5472.CAN-17-1869.

Nie S, Wang X, Sivakumaran P, Chong MMW, Liu X, Karnezis T, Bandara N, Takov K, Nowell CJ, Wilcox S, Shambrook M, Hill AF, Harris NC, Newcomb AE, Strappe P, Shayan R, Hernández D, Clarke J, Hanssen E, Davidson SM, Dusting GJ, Pébay A, Ho JWK, Williamson N, Lim SY. Biologically active constituents of the secretome of human W8B2+ cardiac stem cells. Sci Rep. 2018 Jan 25;8(1):1579. doi: 10.1038/s41598-018-19855-4.


Sisquella X, Ofie-Birin Y, Pimentel MA, Cheng L, Abou Karam P, Sampaio NG, Penington JS, Connolly D, Giladi T, Scicluna BJ, Sharples RA, Waltmann A, Avni D, Schwartz E, Schofield L, Porat Z, Hansen DS, Papenfuss AT, Eriksson EM, Gerlic M, Hill AF, Bowie AG, Regev-Rudzki N. Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors. Nat Commun. 2017 Dec 7;8(1):1985.

Witwer KW, Soekmadji C, Hill AF, Wauben MH, Buzás EI, Di Vizio D, Falcon-Perez JM, Gardiner C, Hochberg F, Kurochkin IV, Lötvall J, Mathivanan S, Nieuwland R, Sahoo S, Tahara H, Torrecilhas AC, Weaver AM, Yin H, Zheng L, Gho YS, Quesenberry P, Théry C. Updating the MISEV minimal requirements for extracellular vesicle studies: building bridges to reproducibility. J Extracell Vesicles. 2017 Nov 15;6(1):1396823. doi: 10.1080/20013078.2017.1396823

Fatima F, Ekstrom K, Nazarenko I, Maugeri M, Valadi H, Hill AF, Camussi G, Nawaz M. Non-coding RNAs in Mesenchymal Stem Cell-Derived Extracellular Vesicles: Deciphering Regulatory Roles in Stem Cell Potency, Inflammatory Resolve, and Tissue Regeneration. Front Genet. 2017 Oct 25;8:161. doi: 10.3389/fgene.2017.00161.

Vella LJ, Behren A, Coleman B, Greening DW, Hill AF, Cebon J. Intercellular Resistance to BRAF Inhibition Can Be Mediated by Extracellular Vesicle-Associated PDGFRβ. Neoplasia. 2017 Sep 27;19(11):932-940.

Vella LJ, Coleman B, Hill AF. Generation of Infectious Prions and Detection with the Prion-Infected Cell Assay. Methods Mol Biol. 2017;1658:105-118. doi: 10.1007/978-1-4939-7244-9_9.

Bellingham SA, Hill AF. Analysis of miRNA Signatures in Neurodegenerative Prion Disease. Methods Mol Biol. 2017;1658:67-80. doi: 10.1007/978-1-4939-7244-9_6.

Vella LJ, Scicluna BJ, Cheng L, Bawden EG, Masters CL, Ang C-S, Williamson N, McLean C, Barnham KJ, Hill AF. A Rigorous method to enrich for exosomes from brain tissue. J Extracell Vesicles. 2017 26 July;6(1):1348885. doi:10.1080/20013078.2017.1348885.

Coumans FAW, Brisson AR, Buzas EI, Dignat-George F, Drees EEE, El-Andaloussi S, Emanueli C, Gasecka A, Hendrix A, Hill AF, Lacroix R, Lee Y, van Leeuwen TG, Mackman N, Mäger I, Nolan JP, van der Pol E, Pegtel DM, Sahoo S, Siljander PRM, Sturk G, de Wever O, Nieuwland R. Methodological Guidelines to Study Extracellular Vesicles. Circ Res. 2017 May 12;120(10):1632-1648. doi: 10.1161/CIRCRESAHA.117.309417.

Lunavat TR, Cheng L, Einarsdottir BO, Olofsson Bagge R, Veppil Muralidharan S, Sharples RA, Lässer C, Gho YS, Hill AF, Nilsson JA, Lötvall J. BRAFV600 inhibition alters the microRNA cargo in the vesicular secretome of malignant melanoma cells. Proc Natl Acad Sci U S A. 2017 Jul 6;114:E5930-E5939. pii: 201705206. doi: 10.1073/pnas.1705206114.

Mateescu B, Kowal EJ, van Balkom BW, Bartel S, Bhattacharyya SN, Buzás EI, Buck AH, de Candia P, Chow FW, Das S, Driedonks TA, Fernández-Messina L, Haderk F, Hill AF, Jones JC, Van Keuren-Jensen KR, Lai CP, Lässer C, Liegro ID, Lunavat TR, Lorenowicz MJ, Maas SL, Mäger I, Mittelbrunn M, Momma S, Mukherjee K, Nawaz M, Pegtel DM, Pfaffl MW, Schiffelers RM, Tahara H, Théry C, Tosar JP, Wauben MH, Witwer KW, Nolte-‘t Hoen EN. Obstacles and opportunities in the functional analysis of extracellular vesicle RNA – an ISEV position paper. J Extracell Vesicles. 2017 Mar 7;6(1):1286095. doi: 10.1080/20013078.2017.1286095.

EV-TRACK Consortium., Van Deun J, Mestdagh P, Agostinis P, Akay Ö, Anand S, Anckaert J, Martinez ZA, Baetens T, Beghein E, Bertier L, Berx G, Boere J, Boukouris S, Bremer M, Buschmann D, Byrd JB, Casert C, Cheng L, Cmoch A, Daveloose D, De Smedt E, Demirsoy S, Depoorter V, Dhondt B, Driedonks TA, Dudek A, Elsharawy A, Floris I, Foers AD, Gärtner K, Garg AD, Geeurickx E, Gettemans J, Ghazavi F, Giebel B, Kormelink TG, Hancock G, Helsmoortel H, Hill AF, Hyenne V, Kalra H, Kim D, Kowal J, Kraemer S, Leidinger P, Leonelli C, Liang Y, Lippens L, Liu S, Lo Cicero A, Martin S, Mathivanan S, Mathiyalagan P, Matusek T, Milani G, Monguió-Tortajada M, Mus LM, Muth DC, Németh A, Nolte-‘t Hoen EN, O’Driscoll L, Palmulli R, Pfaffl MW, Primdal-Bengtson B, Romano E, Rousseau Q, Sahoo S, Sampaio N, Samuel M, Scicluna B, Soen B, Steels A, Swinnen JV, Takatalo M, Thaminy S, Théry C, Tulkens J, Van Audenhove I, van der Grein S, Van Goethem A, van Herwijnen MJ, Van Niel G, Van Roy N, Van Vliet AR, Vandamme N, Vanhauwaert S, Vergauwen G, Verweij F, Wallaert A, Wauben M, Witwer KW, Zonneveld MI, De Wever O, Vandesompele J, Hendrix A. EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research. Nature Methods. 2017 Feb 28;14(3):228-232. doi: 10.1038/nmeth.4185.

Foers AD, Cheng L, Hill AF, Wicks IP, Pang KC. Extracellular vesicles in joint inflammation. Arthritis Rheumatol. Arthritis Rheumatol. 2017 Jul;69(7):1350-1362.

Quek C, Bellingham SA, Jung CH, Scicluna B, Shambrook MC, Sharples R, Cheng L, Hill AF. Defining the purity of exosomes required for diagnostic profiling of small RNA suitable for biomarker discovery. RNA Biol. RNA Biol. 2017 Feb;14(2):245-258.

Cheng L, Hill AF. Small RNA Library Construction for Exosomal RNA from Biological Samples for the Ion Torrent PGM™ and Ion S5™ System. Methods Mol Biol. 2017;1545:71-90

Bellingham SA, Shambrook M, Hill AF. Quantitative Analysis of Exosomal miRNA via qPCR and Digital PCR. Methods Mol Biol. 2017;1545:55-70.

Quek C, Hill AF. The role of extracellular vesicles in neurodegenerative diseasesBiochem Biophys Res Commun. 2017 Feb 19;483(4):1178-1186.


Howitt J, Hill AF. Exosomes in the Pathology of Neurodegenerative Diseases. J Biol Chem. 2016; 291 (52), 26589-26597.

Gardiner C, Di Vizio D, Sahoo S, Théry C, Witwer KW, Wauben M, Hill AF. Techniques used for the isolation and characterization of extracellular vesicles: results of a worldwide survey.  J Extracell Vesicles. 2016 Oct 31;5:32945.

Vogel R, Coumans FA, Maltesen RG, Böing AN, Bonnington KE, Broekman ML, Broom MF, Buzás EI, Christiansen G, Hajji N, Kristensen SR, Kuehn MJ, Lund SM, Maas SL, Nieuwland R, Osteikoetxea X, Schnoor R, Scicluna BJ, Shambrook M, de Vrij J, Mann SI, Hill AF, Pedersen S. A standardized method to determine the concentration of extracellular vesicles using tunable resistive pulse sensing. J Extracell Vesicles. 2016 Sep 27;5:31242. doi: 10.3402/jev.v5.31242.

Ugalde CL, Finkelstein DI, Lawson VA, Hill AF. Pathogenic mechanisms of prion protein, amyloid-β and α-synuclein misfolding: the prion concept and neurotoxicity of protein oligomers. J Neurochem. 2016 Oct;139(2):162-180. doi: 10.1111/jnc.13772.

Krämer-Albers E-M, Hill AF. Extracellular vesicles: interneural shuttles of complex messages. Current Opinion in Neurobiology. 2016;39:101-107. doi: 10.1016/j.conb.2016.04.016

Cheung K-H, Keerthikumar S, Roncaglia P, Subramanian, Roth ME, Samuel M, Anand S, Gangoda L, Gould S, Alexander R, Galas D, Gerstein MB, Hill AF, Kitchen RR, Lotvall J, Patel T, Procaccini DC, Quesenbery P, Rozowsky J, Raffai RI, Shypitsyna A, Su AI, Thery C, Vickers K, Wauben MHM, Mathivanan S, Molisavljevic A, Laurent LC. Extending gene ontology in the context of extracellular RNA and vesicle communicationJ Biomed Seman. 2016 7:19.

Polanco JC, Scicluna BJ, Hill AF, Gotz J. Extracellular vesicles isolated from brains of rTg4510 mice seed tau protein aggregation in a threshold-dependent mannerJ  Biol Chem. 2016 Mar 30;291:12445-12466.

François M, Fenech MF, Thomas P, Hor M, Rembach A, Martins RN, Rainey-Smith SR, Masters CL, Ames D, Rowe CC, Lance Macaulay S, Hill AF, Leifert WR, The Australian Imaging Biomarkers And Lifestyle Study Research Group. High content, multi-parameter analyses in buccal cells to identify Alzheimer’s disease. Curr Alzheimer Res. 2016 Mar 15;13:787-799.

Silverman JM, Fernando SM, Grad LI, Hill AF, Turner BJ, Yerbury JJ, Cashman NR. Disease Mechanisms in ALS: Misfolded SOD1 Transferred Through Exosome-Dependent and Exosome-Independent PathwaysCell Mol Neurobiol. 2016 Feb 23;36:377-381.

Cheng L, Quek CYJ, Hung LW, Sharples RA, Sherratt NA, Barnham KJ, Hill AF. Gene dysregulation is restored in the Parkinson’s disease MPTP neurotoxic mice model upon treatment of the therapeutic drug CuII(atsm). Scientific Reports. 2016 March 1;6:22398. doi: 10.1038/srep22398.

Vella LJ, Hill AF*, Cheng L. Focus on Extracellular Vesicles: Exosomes and Their Role in Protein Trafficking and Biomarker Potential in Alzheimer’s and Parkinson’s Disease. International Journal of Molecular Sciences. 2016, 17(2), 173; doi:10.3390/ijms17020173 (*corresponding author)

Guo BB, Bellingham SA, Hill AF. Stimulating the release of exosomes increases the intercellular transfer of prions. J Biol Chem. 2016 Jan 14;291:5128-5137. pii: jbc.M115.684258.

Low H, Cheng L, Di Yacovo M-S, Churchill MJ, Meikle P, Bukrinsky M, Hill AF, Sviridov D. Lipid metabolism in patients infected with Nef-deficient HIV-1 strain. Atherosclerosis. 2016, 244;22-28.


Lener T, Gimona M, Aigner L, Börger V, Buzas E, Camussi G, Chaput N, Chatterjee D, Court FA, Del Portillo HA, O’Driscoll L, Fais S, Falcon-Perez JM, Felderhoff-Mueser U, Fraile L, Gho YS, Görgens A, Gupta RC, Hendrix A, Hermann DM, Hill AF, Hochberg F, Horn PA, de Kleijn D, Kordelas L, Kramer BW, Krämer-Albers EM, Laner-Plamberger S, Laitinen S, Leonardi T, Lorenowicz MJ, Lim SK, Lötvall J, Maguire CA, Marcilla A, Nazarenko I, Ochiya T, Patel T, Pedersen S, Pocsfalvi G, Pluchino S, Quesenberry P, Reischl IG, Rivera FJ, Sanzenbacher R, Schallmoser K, Slaper-Cortenbach I, Strunk D, Tonn T, Vader P, van Balkom BW, Wauben M, Andaloussi SE, Théry C, Rohde E, Giebel B. Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper. J Extracell Vesicles. 2015 Dec 31;4:30087.

Polling S, Ormsby AR, Wood RJ, Lee K, Shoubridge C, Hughes JN, Thomas PQ, Griffin MD, Hill AF, Bowden Q, Böcking T, Hatters DM. Polyalanine expansions drive a shift into α-helical clusters without amyloid-fibril formation. Nat Struct Mol Biol. 2015 Nov 16;22:1008-1015.

Quek C, Jung CH, Bellingham SA, Lonie A, Hill AF. iSRAP – a one-touch research tool for rapid profiling of small RNA-seq data. Journal of Extracellular Vesicles. 2015, 4: 29454 –

De Mario A, Castellani A, Peggion C, Massimino ML, Lim D, Hill AF, Sorgato MC, Bertoli A. The prion protein constitutively controls neuronal store-operated Ca2+ entry through Fyn kinase Frontiers in Cellular Neuroscience. 2015 Oct 28;9(416):1-11.

Lunavat TR, Cheng L, Kim D-K, Bhadury J, Jang SC, Lasser C, Sharples RA, Lopez MD, Nilsson J, Gho YS, Hill AF, Lotvall J. Small RNA deep sequencing discriminates subsets of extracellular vesicles released by melanoma cells – evidence of unique microRNA cargos. RNA Biology. 2015 Aug 3;12(8):810-23.

Bellingham SA, Guo BB, Hill AF. The secret life of extracellular vesicles in metal homeostasis and neurodegeneration. Biology of the Cell. 2015, June 1;107:389-418.

Sviridov D, Hill AF. Atherosclerosis: cell biology and lipoproteins. Not a day without microRNA. Current Opinion in Lipidology. 2015 Aug;26(4):355-6.

Pathan M, Keerthikumar S, Ang C-S, Gangoda L, Quek CYJ, Williamson NA, Mouradov D, Sieber OM, Simpson RJ, Salim A, Bacic A, Hill AF, Stroud DA, Ryan MT, Agbinya JI, Mariadasson JM, Burgess AW, Mathivanan S. FunRich: An open access standalone functional enrichment and interaction network analysis tool. Proteomics. 2015 Aug;15(15):2597-601.

Ellet LJ, Coleman BM, Shambrook M, Johanssen V, Collins SJ, Masters CL, Hill AF, Lawson VA. Glycosaminoglycan Sulfation Determines the Biochemical Properties of Prion Protein Aggregates. Glycobiology. 2015 Jul;25(7):745-55.

Coleman BM, Hill AF. Extracellular vesicles – their role in the packaging and spread of misfolded proteins associated with neurodegenerative diseases. Seminars in Cell and Developmental Biology. 2015 Feb 19;40:89-96.

Johanssen T, Suphantarida N, Donnelly PS, Liu ZM, Petrou S, Hill AF, Barnham KJ. PBT2 Inhibits Glutamate-induced Excitotoxicity in Neurons Through Metal-mediated Preconditioning. Neurobiology of Disease. 2015 Feb 17;81:176-185.

Guo BB, Bellingham SA, Hill AF. The neutral sphingomyelinase pathway regulates packaging of the prion protein into exosomes. J Biol Chem. 2015 Feb 6;290(6):3455-67.

Iqbal Hossain M, Hoque A, Lessene G, Aizuddin Kamaruddin M, Chu PW, Ng IH, Irtegun S, Ng DC, Bogoyevitch MA, Burgess AW, Hill AF, Cheng HC. Dual role of Src kinase in governing neuronal survival. Brain Res. 2015 Jan 12;1594:1-14. doi: 10.1016/j.brainres.2014.10.040.

Kim DK, Lee J, Kim SR, Choi DS, Yoon YJ, Kim JH, Go G, Nhung D, Hong K, Jang SC, Kim SH, Park KS, Kim OY, Park HT, Seo JH, Aikawa E, Baj-Krzyworzeka M, van Balkom BW, Belting M, Blanc L, Bond V, Bongiovanni A, Borràs FE, Buée L, Buzás EI, Cheng L, Clayton A, Cocucci E, Dela Cruz CS, Desiderio DM, Di Vizio D, Ekström K, Falcon-Perez JM, Gardiner C, Giebel B, Greening DW, Gross JC, Gupta D, Hendrix A, Hill AF, Hill MM, Nolte-‘t Hoen E, Hwang DW, Inal J, Jagannadham MV, Jayachandran M, Jee YK, Jørgensen M, Kim KP, Kim YK, Kislinger T, Lässer C, Lee DS, Lee H, van Leeuwen J, Lener T, Liu ML, Lötvall J, Marcilla A, Mathivanan S, Möller A, Morhayim J, Mullier F, Nazarenko I, Nieuwland R, Nunes DN, Pang K, Park J, Patel T, Pocsfalvi G, Del Portillo H, Putz U, Ramirez MI, Rodrigues ML, Roh TY, Royo F, Sahoo S, Schiffelers R, Sharma S, Siljander P, Simpson RJ, Soekmadji C, Stahl P, Stensballe A, Stępień E, Tahara H, Trummer A, Valadi H, Vella LJ, Wai SN, Witwer K, Yáñez-Mó M, Youn H, Zeidler R, Gho YS. EVpedia: a community web portal for extracellular vesicles research. Bioinformatics. 2015 Mar 15;31(6):933-9.

Cheng L, Doecke JD, Sharples RA, Villemagne VL, Fowler CJ, Rembach A, Martins RN, Rowe CC, Macaulay SL, Masters CL, Hill AF. Prognostic serum miRNA biomarkers associated with Alzheimer’s disease shows concordance with neuropsychological and neuroimaging assessment. Mol Psychiatry. 2015;20:1188-1196.


Lötvall J, Hill AF, Hochberg F, Buzás EI, Di Vizio D, Gardiner C, Gho YS, Kurochkin IV, Mathivanan S, Quesenberry P, Sahoo S, Tahara H, Wauben MH, Witwer KW, Théry C. Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles. J Extracell Vesicles. 2014 Dec 22;3:26913. doi:10.3402/jev.v3.26913. eCollection 2014. PubMed PMID: 25536934.

Lopes MH, Santos TG, Rodrigues BR, Queiroz-Hazarbassanov N, Cunha IW, Wasilewska-Sampaio AP, Costa-Silva B, Marchi FA, Bleggi-Torres LF, Sanematsu PI, Suzuki SH, Oba-Shinjo SM, Marie SK, Toulmin E, Hill AF, Martins VR. Disruption of prion protein-HOP engagement impairs glioblastoma growth and cognitive decline and improves overall survival. Oncogene. 2015 Jun;34(25):3305-14.

Cheng L, Sharples RA, Scicluna B, Hill AF. Exosomes provide a protective and enriched source of miRNA for biomarker profiling compared to intracellular and cell-free blood. J Extracell Vesicles. 2014 Mar 26;3:1-14. doi: 10.3402/jev.v3.23743.

Grad LI, Yerbury JJ, Turner BJ, Guest WC, Pokrishevsky E, O’Neill MA, Yanai A, Silverman JM, Zeineddine R, Corcoran L, Kumita JR, Luheshi L, Yousefi M, Coleman BM, Hill AF, Plotkin SS, Mackenzie IR, Cashman NR. Intercellular propagated misfolding of wild-type Cu-Zn superoxide dismutase occurs via exosome-dependent and independent mechanisms. Proc Natl Acad Sci USA. 2014 Mar 4;111(9):3620-5.

Polling S, Mok YF, Ramdzan YM, Turner BJ, Yerbury JJ, Hill AF, Hatters DM. Misfolded polyglutamine, polyalanine, and superoxide dismutase 1 aggregate via distinct pathways in the cell. J Biol Chem. 2014 Mar 7;289(10):6669-80.

Coleman BM, Harrison CF, Guo B, Masters CL, Barnham KJ, Lawson VA, Hill AF. Pathogenic Mutations within the Hydrophobic Domain of the Prion Protein Lead to the Formation of Protease-Sensitive Prion Species with Increased Lethality. J Virol. 2014 Mar;88(5):2690-703. doi: 10.1128/JVI.02720-13.

Johanssen VA, Johanssen T, Masters CL, Hill AF, Barnham KJ, Collins SJ. C-terminal peptides modelling constitutive PrPC processing demonstrate ameliorated toxicity predisposition consequent to α-cleavage. Biochem J. 2014 Apr 1;459(1):103-15. doi: 10.1042/BJ20131378.

Cui HL, Guo B, Scicluna B, Coleman BM, Lawson VA, Ellett L, Meikle PJ, Bukrinsky M, Mukhamedova N, Sviridov D, Hill AF. Prion infection impairs cholesterol metabolism in neuronal cells. J Biol Chem. 2014 Jan 10;289(2):789-802.

Cheng L, Sun X, Scicluna BJ, Coleman BM, Hill AF. Characterization and deep sequencing analysis of exosomal and non-exosomal miRNA in human urine. Kidney Int. 2014 Aug;86(2):433-44.


Hill AF, Pegtel DM, Lambertz U, Leonardi T, O’Driscoll L, Pluchino S, Ter-Ovanesyan D, Nolte-‘t Hoen EN. ISEV position paper: extracellular vesicle RNA analysis and bioinformatics. J Extracell Vesicles. 2013 Dec 23;2:1-8. doi: 10.3402/jev.v2i0.22859.

Hsiao JH, Fu Y, Hill AF, Halliday GM, Kim WS. Elevation in sphingomyelin synthase activity is associated with increases in amyloid-beta peptide generation. PLoS One. 2013 Aug 20;8(8):e74016.

Bujalka H, Koenning M, Jackson S, Perreau VM, Pope B, Hay CM, Mitew S, Hill AF, Lu QR, Wegner M, Srinivasan R, Svaren J, Willingham M, Barres BA, Emery B. MYRF is a membrane-associated transcription factor that autoproteolytically cleaves to directly activate myelin genes. PLoS Biol. 2013;11(8):e1001625. Epub 2013 Aug 13.

Cheng L, Quek CY, Sun X, Bellingham SA, Hill AF. The detection of microRNA associated with Alzheimer’s disease in biological fluids using next-generation sequencing technologies. Front Genet. 2013 Aug 8;4:150.

Chia PZ, Toh WH, Sharples R, Gasnereau I, Hill AF, Gleeson PA. Intracellular itinerary of internalised β-secretase, BACE1, and its potential impact on β-amyloid peptide biogenesis. Traffic. 2013 Sep;14(9):997-1013.

Regev-Rudzki N, Wilson DW, Carvalho TG, Sisquella X, Coleman BM, Rug M, Bursac D, Angrisano F, Gee M, Hill AF, Baum J, Cowman AF. Cell-cell communication between malaria-infected red blood cells via exosome-like vesicles. Cell. 2013 May 23;153(5):1120-33.

Hossain MI, Roulston CL, Kamaruddin MA, Chu PW, Ng DC, Dusting GJ, Bjorge JD, Williamson NA, Fujita DJ, Cheung SN, Chan TO, Hill AF, Cheng HC. A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity. J Biol Chem. 2013 Apr 5;288(14):9696-709.

Tauro BJ, Mathias RA, Greening DW, Gopal SK, Ji H, Kapp EA, Coleman BM, Hill AF, Kusebauch U, Hallows JL, Shteynberg D, Moritz RL, Zhu HJ, Simpson RJ. Oncogenic H-ras reprograms Madin-Darby canine kidney (MDCK) cell-derived exosomal proteins following epithelial-mesenchymal transition. Mol Cell Proteomics. 2013 Aug;12(8):2148-59.


Kalra H, Simpson RJ, Ji H, Aikawa E, Altevogt P, Askenase P, Bond VC, Borràs FE, Breakefield X, Budnik V, Buzas E, Camussi G, Clayton A, Cocucci E, Falcon-Perez JM, Gabrielsson S, Gho YS, Gupta D, Harsha HC, Hendrix A, Hill AF, Inal JM, Jenster G, Krämer-Albers EM, Lim SK, Llorente A, Lötvall J, Marcilla A, Mincheva-Nilsson L, Nazarenko I, Nieuwland R, Nolte-‘t Hoen EN, Pandey A, Patel T, Piper MG, Pluchino S, Prasad TS, Rajendran L, Raposo G, Record M, Reid GE, Sánchez-Madrid F, Schiffelers RM, Siljander P, Stensballe A, Stoorvogel W, Taylor D, Thery C, Valadi H, van Balkom BW, Vázquez J, Vidal M, Wauben MH, Yáñez-Mó M, Zoeller M, Mathivanan S. Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation. PLoS Biol. 2012 Dec;10(12):e1001450

Klemm, HMJ, Welton JM, Masters CL, Hill AF, Collins SJ, Lawson VA. The prion protein preference of sporadic Creutzfeldt-Jakob disease subtypes. Journal of Biological Chemistry 2012 Oct 19;287(43):36465-72.

Bellingham SA, Coleman BM, Hill AF. Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion infected neuronal cells. Nucleic Acids Research (2012) Nov;40(21):10937-49.

Coleman BM, Hanssen E, Lawson VA, Hill AF. Prion infected cells regulate the release of exosomes with distinct ultrastructural features. FASEB Journal. 2012 Oct;26(10):4160-73.

Falsone SF, Meyer NH, Schrank E, Leitinger G, Pham CLL, Fodero-Tavoletti MT, Holmberg M, Nollen EA, Dulle M, Scicluna B, Gesslbauer B, Ruckert HM, Wagner G, Kungl AJ, Hill AF, Cappai R, Zangger K. SERF protein is a direct modifier of amyloid fiber assembly. Cell Reports. 2012; 2 (2), 358-371.

Tu E, Ang DKY, Bellingham SA, Hogan TV, Teng MWL, Smyth MJ, Hill AF, van Driel IR. Both IFNγ and IL-17 are important for the development of severe autoimmune gastritis. European Journal of Immunology. 2012; 42(10), 2574-2583.

Bellingham SA, Guo B, Coleman BM, Hill AF. Exosomes: vehicles for the transfer of toxic proteins associated with neurodegenerative diseases? Frontiers in Physiology. 2012; 3, 1-12.

Lewis V, Haigh CL, Masters CL, Hill AF, Lawson VA, Collins SJ. Prion subcellular fractionation reveals infectivity spectrum, with a high titre-low PrPres level disparity. Molecular Neurodegeneration. 2012; 7:18.

Polling S, Hill AF, Hatters DM. Polyglutamine Aggregation in Huntington and Related Diseases. Adv Exp Med Biol. 2012;769:125-40.

Karas JA, Boland M, Haigh C, Johanssen VA, Hill AF, Barnham KJ, Collins SJ, Scanlon D. Microwave Synthesis of Prion Protein Fragments up to 111 Amino Acids in Length Generates Biologically Active Peptides. International Journal of Peptide Research and Therapy. (2012) 18:21-29.

Hung LW, Villemagne VL, Cheng L, Sherratt NA, Ayton S, White AR, Crouch PJ, Lin SC, Leong S, Wilkins S, George J, Roberts B, Pham CL, Chiu FCK, Shackleford DM, Powell AK, Masters CL, Bush AI, O’Keefe GO, Culvenor JG, Cappai R, Cherny RA, Donnelly PS, Hill AF, Finkelstein DI, Barnham KJ. The hypoxia imaging agent, CuII(atsm), is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson’s disease. Journal of Experimental Medicine. 2012 Apr 9;209(4):837-54.

Li H, Evin G, Hill AF, Hung YH, Bush AI, Garner B. Dissociation of ERK signalling inhibition from the anti-amyloidogenic action of synthetic ceramide analogues. Clin Sci (Lond) 2012;122(9):409-19.

Houghton FJ, Bellingham SA, Hill AF, Bourges D, Ang DK, Gemetzis T, Gasnereau I, Gleeson PA. Arl5b is a Golgi-localised small G protein involved in the regulation of retrograde transport. Exp Cell Res. 2012; 318(5):464-77.

Johanssen VA, Barnham KJ, Masters CL, Hill AF, Collins SJ. Generating recombinant C-terminal prion protein fragments of exact native sequence. Neurochem Int. 2012 Feb;60(3):318-26.


Kim WS, Hill AF, Fitzgerald ML, Freeman MW, Evin G, Garner B. Wild type and Tangier disease ABCA1 mutants modulate cellular amyloid-β production independent of cholesterol efflux activity. J Alzheimers Dis. 2011;27(2):441-52.

Santosa C, Rasche S, Barakat A, Bellingham SA, Ho M, Tan J, Hill AF, Masters CL, McLean C, Evin G. Decreased Expression of GGA3 Protein in Alzheimer’s Disease Frontal Cortex and Increased Co-Distribution of BACE with the Amyloid Precursor Protein. Neurobiol Disease. 2011;43(1):176-83.

Masters CL, Kril JJ, Halliday GM, Pamphlett R, Collins S, Hill AF, McLean C. Overview and recent advances in neuropathology. Part 2: Neurodegeneration. Pathology. 2011 Feb;43(2):93-102.

Dinet V, An N, Ciccotosto GD, Bruban J, Maoui A, Bellingham SA, Hill AF, Andersen OM, Nykjaer A, Jonet L, Cappai R, Mascarelli F. APP involvement in retinogenesis of mice. Acta Neuropathol. 2011 Mar;121(3):351-63.

Vella LJ, Cappai R, Hill AF. The role of exosomes in the pathogenesis of prion infection. In The Cellular and Molecular Biology of Prion Disease, edited by SJ Collins and VA Lawson, Research Signpost, 2011.

Miles LA, Crespi GA, Han S, Hill AF, Parker MW. An Escherichia coli cell-free system for recombinant protein synthesis on a milligram scale. Methods Mol Biol. 2011;752:17-28.


Lawson VA, Furness JB, Klemm HM, Pontell L, Chan E, Hill AF, Chiocchetti R. The brain to gut pathway: a possible route of prion transmission. Gut. 2010 Dec;59(12):1643-51.

Lawson VA, Lumicisi B, Welton J, Machalek D, Gouramanis K, Klemm HM, Stewart JD, Masters CL, Hoke DE, Collins SJ, Hill AF. Glycosaminoglycan sulphation affects the seeded misfolding of a mutant prion protein. PLoS One. 2010 Aug 23;5(8). pii: e12351.

Boland MP, Hatty CR, Separovic F, Hill AF, Tew DJ, Barnham KJ, Haigh CL, James M, Masters CL, Collins SJ. Anionic phospholipid interactions of the prion protein N terminus are minimally perturbing and not driven solely by the octapeptide repeat domain. J Biol Chem. 2010 Oct 15;285(42):32282-92.

Li H, Kim WS, Guillemin GJ, Hill AF, Evin G, Garner B. Modulation of amyloid precursor protein processing by synthetic ceramide analogues. Biochim Biophys Acta. 2010 Aug;1801(8):887-95.

Brazier MW, Volitakis I, Kvasnicka M, White AR, Underwood JR, Green JE, Han S, Hill AF, Masters CL, Collins SJ. Manganese chelation therapy extends survival in a mouse model of M1000 prion disease. J Neurochem. 2010 Jul;114(2):440-51.

Olshina MA, Angley LM, Ramdzan YM, Tang J, Bailey MF, Hill AF, Hatters DM. Tracking mutant huntingtin aggregation kinetics in cells reveals three major populations that include an invariant oligomer pool. J Biol Chem. 2010 Jul 9;285(28):21807-16.

Nisbet RM, Harrison CF, Lawson VA, Masters CL, Cappai R, Hill AF. Residues surrounding the glycosylphosphatidylinositol anchor attachment site of PrP modulate prion infection: insight from the resistance of rabbits to prion disease. J Virol. 2010 Jul;84(13):6678-86.

Ramdzan YM, Nisbet RM, Miller J, Finkbeiner S, Hill AF, Hatters DM. Conformation sensors that distinguish monomeric proteins from oligomers in live cells. Chem Biol. 2010 Apr 23;17(4):371-9.

Perreau VM, Orchard S, Adlard PA, Bellingham SA, Cappai R, Ciccotosto GD, Cowie TF, Crouch PJ, Duce JA, Evin G, Faux NG, Hill AF, Hung YH, James SA, Li QX, Mok SS, Tew DJ, White AR, Bush AI, Hermjakob H, Masters CL. A domain level interaction network of amyloid precursor protein and Abeta of Alzheimer’s disease. Proteomics. 2010 Jun;10(12):2377-95.

Harrison CF, Lawson VA, Coleman BM, Kim YS, Masters CL, Cappai R, Barnham KJ, Hill AF. Conservation of a glycine-rich region in the prion protein is required for uptake of prion infectivity. J Biol Chem. 2010 Jun 25;285(26):20213-23.

Tabrett CA, Harrison CF, Schmidt B, Bellingham SA, Hardy T, Sanejouand YH, Hill AF*, Hogg PJ. Changing the solvent accessibility of the prion protein disulfide bond markedly influences its trafficking and effect on cell function. Biochem J. 2010 May 13;428(2):169-82. (* corresponding author).


Lewis V, Hill AF, Haigh CL, Klug GM, Masters CL, Lawson VA, Collins SJ. Increased proportions of C1 truncated prion protein protect against cellular M1000 prion infection. J Neuropathol Exp Neurol. 2009 Oct;68(10):1125-35.

Haigh CL, Lewis VA, Vella LJ, Masters CL, Hill AF, Lawson VA, Collins SJ. PrPC-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site. Cell Res. 2009 Sep;19(9):1062-78.

Hill AF. Exosomes in Neurological Disease. Curr Med Literature Neurology. 2009;16(1);27-32.

Pham CL, Leong SL, Ali FE, Kenche VB, Hill AF, Gras SL, Barnham KJ, Cappai R. Dopamine and the dopamine oxidation product 5,6-dihydroxylindole promote distinct on-pathway and off-pathway aggregation of alpha-synuclein in a pH-dependent manner. J Mol Biol. 2009 Apr 3;387(3):771-85.

Coleman BM, Nisbet RM, Han S, Cappai R, Hatters DM, Hill AF. Conformational detection of prion protein with biarsenical labeling and FlAsH fluorescence. Biochem Biophys Res Commun. 2009 Mar 13;380(3):564-8.

Leong SL, Pham CL, Galatis D, Fodero-Tavoletti MT, Perez K, Hill AF, Masters CL, Ali FE, Barnham KJ, Cappai R. Formation of dopamine-mediated alpha-synuclein-soluble oligomers requires methionine oxidation. Free Radic Biol Med. 2009 May 15;46(10):1328-37.

Bellingham SA, Coleman LA, Masters CL, Camakaris J, Hill AF. Regulation of prion gene expression by transcription factors SP1 and MTF-1. J Biol Chem. 2009 Jan 9;284(2):1291-301.

Kim WS, Chan SL, Hill AF, Guillemin GJ, Garner B. Impact of 27-hydroxycholesterol on amyloid-beta peptide production and ATP-binding cassette transporter expression in primary human neurons, Journal of Alzheimers Disease. 2009;16(1):121-31.


Lawson VA, Vella L, Stewart JD, Sharples R, Klemm H, Machalek DM, Masters CL, Cappai R, Collins SJ, Hill AF. Mouse adapted sporadic human CJD prions propagate in cell culture. International Journal of Biochemistry and Cell Biology. 2008;40(12):2793-801.

Vella LJ, Greenwood D, Cappai R, Scheerlinck JPY, Hill AF. Enrichment of prion protein in exosomes derived from ovine cerebral spinal fluid. Veterinary Immunology and Immunopathology. 2008, 124:385-393.

Chan SL, Kim WS, Kwok JB, Hill AF, Cappai R, Rye K, Garner B. ATP-binding cassette transporter A7 inhibits amyloid beta production in vitro. Journal of Neurochemistry. 2008 Jul;106(2):793-804.

Collinge J, Whitfield J, McKintosh E, Frosh A, Mead S, Hill AF, Brandner S, Thomas D, Alpers MP. A clinical study of kuru patients with long incubation periods at the end of the epidemic in Papua New Guinea. Trans. R. Soc. B. 2008 Nov 27;363(1510):3725-39.

Albanese V, Lawson VA, Hill AF, Cappai R, Di Guardo G, Staikopoulos V, Thacker M, Furness JB, Chiocchetti R. Evidence for prion protein expression in enteroglial cells of the myenteric plexus of mouse intestine. Auton Neurosci. 2008 Jun;140(1-2):17-23.

Price KA, Filiz G, Caragounis A, Du T, Laughton K, Masters CL, Sharples RA, Hill AF, Li QX, Donnelly P, Barnham KJ, Crouch PJ, White AR. Activation of epidermal growth factor receptor by metal-ligand complexes decreases levels of extracellular amyloid beta peptide. International Journal of Biochemistry & Cell Biology. 2008;40(9):1901-17.

Wadsworth JDF, Joiner S, Linehan JM, Desbruslais M, Fox M, Cooper S, Cronier S, Asante EA, Mead S, Brander S, Hill AF, Collinge J. Kuru prions and sporadic CJD prions have equivalent transmission properties in transgenic and wild type mice. Proceedings of the National Academy of Sciences USA. 2008 Mar 11;105(10):3885-90.

Naylor, R, Hill AF, Barnham KJ. Is Covalently Crosslinked A-beta Responsible for Synaptotoxicity in Alzheimer’s Disease? Current Alzheimer Research. 2008 5(6); 533-539.

Vella LJ, Hill AF. Generation of cell lines propagating infectious prions and the isolation of cell derived exosomes. Methods Mol Biol. 2008;459:69-82.

Han S, Hill AF. Analysis of PrP conformation using circular dichroism. Methods Mol Biol. 2008;459:145-59.

Lewis V, Klug GM, Hill AF, Collins SJ. Molecular typing of PrPres in human sporadic CJD brain tissue. Methods Mol Biol. 2008;459:241-7.

Smith DP, Tew DJ, Hill AF, Bottomley SP, Masters CL, Barnham KJ, Cappai R. Formation of a High Affinity Lipid-Binding Intermediate during the Early Aggregation Phase of alpha-Synuclein. Biochemistry. 2008 Feb 5;47(5):1425-1434.

Sharples RA, Vella LJ, Nisbet RM, Naylor R, Perez K, Barnham KJ, Masters CL, Hill AF. Inhibition of {gamma}-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes. FASEB J. 2008 May;22(5):1469-78.

Courageot MP, Daude N, Nonno R, Paquet S, Di Bari MA, Le Dur A, Chapuis J, Hill AF, Agrimi U, Laude H, Vilette D. A cell line infectible by prion strains from different species. J Gen Virol. 2008 Jan;89(Pt 1):341-7.

Donnelly PS, Caragounis A, Du T, Laughton KM, Volitakis I, Cherny RA, Sharples RA, Hill AF, Li QX, Masters CL, Barnham KJ, White AR. Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer’s disease amyloid-beta peptide. J Biol Chem. 2008 Feb 22;283(8):4568-77.

Vella LJ, Sharples RA, Nisbet RM, Cappai R, Hill AF. The role of exosomes in the processing of proteins associated with neurodegenerative diseases. Eur Biophys J. 2008 Mar;37(3):323-32.

Naylor R, Hill AF, Barnham KJ. Neurotoxicity in Alzheimer’s disease: is covalently crosslinked Abeta responsible? Eur Biophys J. 2008 Mar;37(3):265-8.


Harrison CF, Barnham KJ, Hill AF. Neurotoxic species in prion disease: a role for PrP isoforms? J Neurochem. 2007 Dec;103(5):1709-20.

Caragounis A, Du T, Filiz G, Laughton KM, Volitakis I, Sharples RA, Cherny RA, Masters CL, Drew SC, Hill AF, Li QX, Crouch PJ, Barnham KJ, White AR. Differential modulation of Alzheimer’s disease amyloid beta-peptide accumulation by diverse classes of metal ligands. Biochem J. 2007 Nov 1;407(3):435-50.

Kim WS, Suryo Rahmanto A, Kamili A, Rye KA, Guillemin GJ, Gelissen IC, Jessup W, Hill AF, and Garner B. Role of ABCG1 and ABCA1 in regulation of neuronal cholesterol efflux to apolipoprotein-E discs and suppression of amyloid-beta peptide generation. J Biol Chem. 2007;282(5):2851-61.

Hill AF, Barnham KJ, Response to Ji et al: why prion diseases are precluded by non-mammals. Trends Biochem.Sci. 32, 208-208 (2007).

Vella LJ, Sharples RA, Lawson VA, Masters CL, Cappai R, Hill AF. Packaging of prions into exosomes is associated with a novel pathway of PrP processing. Journal of Pathology 2007 Apr;211(5):582-90.


Sim CH, Lio DS, Mok SS, Masters CL, Hill AF, Culvenor JG, Cheng HC. C-terminal truncation and Parkinson’s disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1. Hum Mol Genet. 2006, 15(21):3251-62.

White AR, Du T, Laughton KM, Volitakis I, Sharples RA, Xilinas ME, Hoke DE, Holsinger RM, Evin G, Cherny RA, Hill AF, Barnham KJ, Li QX, Bush AI, and Masters CL. Degradation of the Alzheimer Disease Amyloid beta-Peptide by Metal-dependent Up-regulation of Metalloprotease Activity. J Biol Chem. 2006 Jun 30;281(26):17670-80.

Wilson LM, Pham CLL, Jenkins AJ, Wade JD, Hill AF, Perugini MA, Howlett GJ. High density lipoproteins bind Aβ and apolipoprotein C-II amyloid fibrils. Journal of Lipid Research. 2006 Apr;47(4):755-60.

Hill AF, Joiner S, Beck JA, Campbell TA, Dickinson A, Poulter M, Wadsworth JDF, Collinge J. Distinct glycoform ratios of protease resistant prion protein associated with PRNP point mutations. Brain. 2006 Mar;129(Pt 3):676-85.

Barnham KJ, Cappai R, Beyreuther K, Masters CL, Hill AF. Delineating common molecular mechanisms in Alzheimer’s and prion diseases. Trends in Biochemical Sciences. 2006, 31(8):465-72.

Brazier MW, Lewis V, Ciccotosto GD, Klug GM, Lawson VA, Cappai R, Ironside JW, Masters CL, Hill AF, White AR, Collins SJ. Correlative studies support lipid peroxidation is linked to PrP(res) propagation as an early primary pathogenic event in prion disease. Brain Research Bulletin. 2006 Jan 30;68(5):346-54.


Collins SJ, Lewis VL, Brazier MW, Hill AF, Lawson VA, Klug GM, Masters CL. Extended period of asymptomatic prion disease after low dose inoculation: assessment of detection methods and implications for infection control. Neurobiology of Disease. 2005, 20(2):336-346.

Lawson VA, Collins SJ, Masters CL, Hill AF. Prion protein glycosylation. Journal of Neurochemistry. 2005; 93: 793-801.

Yuan FF, Biffin S, Brazier MW, Suarez M, Cappai R, Hill AF, Collins SJ, Sullivan JS, Middleton D, Multhaup G, Geczy AF, Masters CL. Detection of prion epitopes on PrPC and PrPSc of transmissible spongiform encephalopathies using monoclonal antibodies to PrP. Immunology and Cell Biology. 2005; 83 (6): 632-637.

Lewis V, Hill AF, Klug G, Boyd A, Masters CL, Collins SJ. Australian sporadic CJD analysis supports endogenous determinants of molecular-clinical profiles. Neurology. 2005, 65(1):113-118.

Cappai R, Leck S-L, Tew DJ, Williamson NA, Smith DP, Galatis D, Sharples RA, Curtain CC, Ali FE, Cherny RA, Culvenor JG, Bottomley SP, Masters CL, Barnham KJ, Hill AF. Dopamine promotes α–synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway. FASEB Journal. 2005, 19(8).

Turner BJ, Atkin JD, Farg MA, Zang DW, Rembach A, Lopes EC, Patch JD, Hill AF, Cheema SS. Impaired extracellular secretion of mutant superoxide dismutase 1 associates with neurotoxicity in familial amyotrophic lateral sclerosis. J Neuroscience. 2005; 25(1):108-17.


Wadsworth JD, Asante EA, Debruslais M, Linehan JM, Joiner S, Gowland I, Welch J, Stone L, Lloyd SE, Hill AF, Brandner S, Collinge J. Human prion protein V129 prevents expression of variant CJD phenotype. Science. 2004 Dec 3;306(5702):1793-6.

Hill AF. Identification of a new prion strain in cattle – is there more than one form of BSE? Australian Veterinary Journal, 2004; 82(5), 288-91.

Hill AF, Collinge J. Prion strains and species barriers. Contributions to Microbiology, 2004;11, 33-49.


Hill AF, Collinge J. Subclinical prion infection. Trends in Microbiology. 2003;11(12):578-84. (cover article).

Nunan J, Williamson NA, Hill AF, Sernee MF, Masters CL, Small DH. Proteasome-mediated degradation of the C-terminus of the Alzheimer’s disease beta-amyloid protein precursor: effect of C-terminal truncation on production of beta-amyloid protein. J Neurosci Res. 2003;74(3):378-85.

Lewis V, Collins S, Hill AF, Boyd A, McLean CA, Smith M, Masters CL. Novel prion protein insert mutation associated with prolonged neurodegenerative illness. Neurology 2003, 60(10), 1620-4.

Hill AF, Asante E, Collinge J. Bioassays for prions. In Prions and Mad Cow Disease, edited by Brian Nunnally and Ira Krull, Dekker Press, New York, 2003.

Wadsworth JD, Hill AF, Beck JA, Collinge J. Molecular and clinical classification of human prion disease. Br Med Bull. 2003;66:241-54.

Hill AF, Collinge J. Subclinical prion infection in humans and animals. Br Med Bull. 2003;66:161-70.

Hill AF, Joiner S, Wadsworth JDF, Sidle KCL, Bell JE, Budka H, Ironside J, Collinge J. Molecular classification of sporadic Creutzfeldt-Jakob disease. Brain. 2003, 126: 1333-46.

Hill AF. Possible link between bovine spongiform encephalopathy and sporadic Creutzfeldt-Jakob disease. Australian Veterinary Journal. 2003, 81(5): 275-6.


Asante E, Linehan JM, Desbruslais M, Joiner S, Gowland I, Wood AL, Welch J, Hill AF, Lloyd SE, Wadsworth JDF, Collinge J. BSE prions propagate as either variant CJD-like or sporadic CJD-like prion strains in transgenic mice expressing human prion protein. EMBO J. 2002;21(23):6358-66.

Collins SJ, Lewis V, Brazier M, Hill AF, Fletcher A, Masters CL. Quinacrine does not prolong survival in a murine Creutzfeldt-Jakob disease model. Annals of Neurology. 2002 Oct;52(4):503-6.

Hill AF, Collinge J. Species barrier independent prion replication in apparently resistant species. APMIS. 2002;110:44-53.

Collins S, Boyd A, Fletcher A, Kaldor J, Hill AF, Farish S, McLean C, Ansari A, Smith M, Masters CL. Creutzfeldt-Jakob disease cluster in an Australian rural city. Annals of Neurology. 2002 Jul;52(1):115-8. (IF: 7.7)


Wadsworth JDF, Joiner S, Hill AF, Campbell TA, Desbruslais M, Collinge J. Tissue distribution of protease resistant prion protein in variant CJD using a highly sensitive immuno-blotting assay. Lancet. 2001;358:171-180.

Hill AF, Collinge J. Strain variations & species barriers. Contributions to Microbiology. 2001;7:48-57.

White AR, Guirguis R, Brazier MW, Jobling MF, Hill AF, Beyreuther K, Barrow CJ, Masters CL, Collins SJ, Cappai R. Sub-lethal concentrations of prion peptide PrP106-126 or the amyloid beta peptide of Alzheimers disease activates expression of pro-apoptotic markers in primary cortical neurons. Neurobiology of Disease. 2001;8:299-316.


Hill AF, Joiner S, Linehan J, Desbruslais M, Lantos PL, Collinge J. Species-barrier-independent prion replication in apparently resistant species. Proc Natl Acad Sci USA. 2000;97:10248-53.


Almer G, Hainfellner JA, Brucke T, Jellinger K, Kleinert R, Bayer G, Windl O, Kretzschmar HA, Hill AF, Sidle K, Collinge J, Budka H. Fatal Familial Insomnia: A New Austrian Family. Brain. 1999;122:5-16.

Hill AF, Antoniou M, Collinge J. Protease resistant prion protein produced in vitro lacks detectable infectivity. Journal of General Virology. 1999;80:11-14.

Hill AF, Butterworth RJ, Joiner S, Jackson G, Rossor MN, Thomas DJ, Frosh A, Tolley N, Bell JE, Spencer M, King A, Al-Sarraj S, Ironside JW, Lantos PL, Collinge J. Investigation of variant Creutzfeldt-Jakob disease and other human prion diseases with tonsil biopsy samples. Lancet. 1999;353:183-189.

Jackson GS, Hosszu LP, Power A, Hill AF, Kenney J, Saibil H, Craven CJ, Waltho JP, Clarke AR, Collinge J. Reversible Conversion of Monomeric Human Prion Protein Between Native and Fibrillogenic Conformations. Science. 1999;283:1953-1957.

Jackson GS, Hill AF, Joseph C, Hosszu L, Power A, Waltho JP, Clarke AR, Collinge J. Multiple Folding Pathways for Heterologously Expressed Human Prion Protein. Biochem Biophys Acta. 1999;1431:1-13.

Wadsworth JDF, Hill AF, Joiner S, Jackson GS, Clarke AR, Collinge J. Strain-specific prion-protein conformation determined by metal ions. Nature Cell Biology. 1999;1:55-59.

Wadsworth JDF, Jackson GS, Hill AF, Collinge J. Molecular biology of prion propagation. Current Opinion in Genetics & Development. 1999;9:338-345.


Piccardo P, Langeveld JPM, Hill AF, Dlouhy SR, Young K, Giaccone G, Rossi G, Bugiani M, Bugiani O, Meloen RH, Collinge J, Tagliavini F, Ghetti B. An Antibody Raised Against a Conserved Sequence of the Prion Protein Recognises Pathological Isoforms in Human and Animal Prion Diseases, Including Creutzfeldt-Jakob Disease and BSE. American Journal of Pathology. 1998;152:1415-1420.

Jackson G, Hill AF, Joseph C, Clarke A, Collinge J. Structural properties of recombinant human prion protein. In Prions and Brain Diseases in Animals and Humans, edited by Morrison, Plenum Press, New York, 1998, pp197-202.

Hill AF, Sidle KCL, Joiner S, Keyes P, Martin TC, Dawson M, Collinge J. Molecular screening of sheep for bovine spongiform encephalopathy. Neuroscience Letters. 1998;255:159-162.


Collinge J, Hill AF, Sidle KCL, Ironside J. Typing prion isoforms – Reply. Nature. 1997;386:233-234.

Deslys JP, Lasmézas CI, Streichenberger N, Hill AF, Collinge J, Dormont D, Kopp N. New variant Creutzfeldt-Jakob disease in France. Lancet. 1997;349:30-31.

Hill AF, Zeidler M, Ironside J, Collinge J. Diagnosis of variant Creutzfeldt-Jakob disease by tonsil biopsy. Lancet. 1997;349:99-100.

Hill AF, Desbruslais M, Joiner S, Sidle KCL, Gowland I, Doey LJ, Lantos P, Collinge J. The same prion strain causes vCJD and BSE. Nature. 1997;389:448-450.

Collinge J, Palmer MS, Sidle KCL, Hill AF, Gowland I, Meads J, Asante E, Bradley R, Doey LJ, Lantos PL. Addendum: Unaltered susceptibility to BSE in transgenic mice expressing human prion protein.  Nature.  1997;389(6650):526-526.

Hill AF, Will RG, Ironside J, Collinge J. Type of prion protein in UK farmers with Creutzfeldt-Jakob Disease. Lancet. 1997;350:188.

Collinge J, Hill AF, Ironside J, Zeidler M. Diagnosis of new variant Creutzfeldt-Jakob disease by tonsil biopsy – Reply. Lancet. 1997;349 (9061):1323.

Collinge J, Hill AF, Sidle KCL, Ironside J. Biochemical typing of scrapie strains – Reply. Nature. 1997;386:564.


Collinge J, Sidle KCL, Meads J, Ironside J, Hill AF. Molecular Analysis of prion strain variation and the aetiology of ‘new variant’ CJD. Nature.1996;383:685-690.


Whittington MA, Sidle KC, Gowland I, Meads J, Hill AF, Palmer MS, Jefferys JGR, Collinge J. Erratum, Corrigendum: Rescue of neurophysiological phenotype seen in PRP null mice by transgene encoding human prion protein.  Nature Genetics.  1995;9:451-451.

Whittington MA, Sidle KCL, Gowland I, Meads J, Hill AF, Palmer MS, Jefferys JGR, Collinge J. Rescue of neurophysiological phenotype seen in PrP null mice by transgene encoding human prion protein. Nature Genetics. 1995;9:197-201.

Collinge J, Palmer MS, Sidle KCL, Hill AF, Gowland I, Meads J, Asante E, Bradley R, Doey LJ, Lantos PL. Unaltered susceptibility to BSE in transgenic mice expressing human PrP. Nature. 1995;378:779-783.


Palmer MS, Mahal SP, Campbell TA, Hill AF, Sidle KCL, Laplanche JL, Collinge J. Deletions in the prion protein gene are not associated with CJD. Human Molecular Genetics. 1993;2:541-544.


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